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Paul Harvey Podcast

Welcome to the Paul Harvey Podcast. This podcast features the best stories from Paul Harvey's News and Comment and The Rest of the Story shows. He blended news reporting along with an expression of his personal values: love of God and America, Midwestern roots, heart-warming tales of average Americans, family values, and optimism for the future of America. Mr. Harvey was a broadcaster for more than half a century on the ABC News Network with a weekly audience of more than 24 million. He was recognized many times including the Horatio Alger Award and the Presidential Medal of Freedom, the United States' most prestigious civilian award. Mr. Harvey passed at age 90 in 2009.

The format for this podcast is rebroadcasting his News and Comment and The Rest of the Story shows. Unfortunately, few of his News and Comment shows are available. They will be featured once or twice a month and I will attempt to schedule them to coincide with major U.S. holidays related to the show topic. With the large library of Rest of the Story shows, I will group them into common themes that will run for three or four consecutive podcast episodes. Most podcast episodes will be about four minutes in length. I will do my best to clean the audio quality of the audio recordings. Sometimes I will post a follow-up PDF document to the podcast that relates to the episode topic. Most of those PDF documents will come from Wikipedia.

This podcast is part of the LifePodcast Network composed of family friendly podcasts that bring a positive message of hope and inspiration. Check out the LifePodcast Network by clicking on this link,  I am a professor of history at the University of Minnesota.  Check out my personal website at to learn more about me and my research.

This podcast is available through the following podcast directories and apps. Click on the link to go to their website to subscribe for future podcast episodes. iTunes, LibsynGoogle Play MusicStitcherTuneIn ,, Player FM, Overcast, Spotify, Pocket Casts, iCatcher, RSSRadio, and Castamatic.  Websites: and the Paulharveypodcast Facebook page. Follow our Twitter account, @paulharveypod 

Please post comments to the individual episodes, post to the iTunes podcast review and rating section, and email to me. Thanks for listening, David Arendale,

Feb 27, 2018

Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. Much of this is believed to be due to decreased production of prostaglandins and TXA2. Aspirin's ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme. Cyclooxygenase is required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors. However, other effects of aspirin, such as uncoupling oxidative phosphorylation in mitochondria, and the modulation of signaling through NF-κB, are also being investigated. Some of its effects are like those of salicylic acid, which is not an acetylating agent.